Pharmaceutical Chemicals

Synthetic Nucleosides and protected nucleosides by Chemo-Enzymatic Hybrid Process

The company has developed a two-step chemical reaction process for manufacturing nucleosides and their analogs. Four kinds of high quality deoxynucleosides are available and feature:

Reliable traceability
Clear impurity profile
No animal ingredient

Chemo-enzymatic Hybrid Process

  1. The production of sugar phosphates stereoselectively and;
  2. The enzymatic coupling process of sugar phosphates with bases in a regio- and stereo-selective manner (see below).

Out process consists of following two step reactions.

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Deoxy-Nucleosides

Chiral Cobalt Catalysts are suitable for a wide variety of Aryl compounds. The cobalt catalysts are easily accessible reducing agents (NaBH4) and offer a convenient operation

Deoxy-Nucleosides

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Protected Nucleosides
High purity 5'-DMT-protected derivatives for Amidite Nucleosides

The company uses a sophisticated chemical process using its synthetic deoxynucleosides to produce high quality protected nucleosides.

Protected Nucleosides High purity 5'-DMT-protected derivatives for Amidite Nucleosides

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Protected Deoxy-Nucleosides

Protected Deoxy-Nucleosides

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Unnatural Nucleosides

(Application of the Chemo-Enzymatic Hybrid Process)
Mitsui Chemicals' enzymatic coupling process produces unnatural nucleosides stereo-selectively from dR-P and unnatural bases.

Unnatural Nucleosides