Report on the Fourth Mitsui Chemicals International Symposium on Catalysis Science (MICS2009)

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Mitsui Chemicals Catalysis Science Award of Encouragement Commemorative Lecture

Assistant Prof. Yoshiaki Nakao (Kyoto University, Japan)

Carbon-Carbon Bond Forming Addition Reactions Catalyzed Cooperatively by Nickel and Lewis Acid
Assistant Prof. Yoshiaki Nakao

Dr. Nakao has developed new Carbon-Carbon bond forming addition reactions through C-H and C-C bond activation by the cooperative action of nickel catalysts with Lewis acids.

Dr. Nakao has uncovered a unique nickel catalyst for C-H bond activation, although nickel has been rarely employed for this activation. Additionally, he has discovered that use of a Lewis acid facilitates the activation of C-H bonds. Using this cooperative catalyst, he has achieved direct C-H functionalization under mild conditions and has succeeded in promoting addition reactions of nitriles across unsaturated bonds through the activation of the C-CN bonds.

In this lecture, he introduced the addition reaction of pyridine across alkynes, the carbocyanation reactions of alkynes, and uncovering of key reaction intermediates.

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