Report on the Fourth Mitsui Chemicals International Symposium on Catalysis Science (MICS2009)

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Congratulations to Prof. Ei-ichi Negishi on being awarded the 2010 Nobel Prize in Chemistry.
Prof. Negishi was a lecturer at the Fourth Mitsui Chemicals International Symposium on Catalysis Science held in 2009.

Invited Lecture

Prof. Ei-ichi Negishi (Purdue University, U.S.A.)

The Nobel Prize in Chemistry 2009 was awarded to Prof. Prof. Ei-ichi Negishi who was one of the lecturers at MICS2009. Congratulations!

Transition Metal-Catalyzed Organometallic C-C Bond Formation Reactions That Have Revolutionized Organic Synthesis
Prof. Ei-ichi Negishi

Prof. Negishi is a pioneer in the area of transition metal-catalyzed organic synthesis. He discovered or co-discovered a number of reactions for Carbon-Carbon bond formation, notably: (a) Pd-catalyzed cross-coupling with organometals containing Al, Zn, and Zr (this reaction is widely known as “Negishi Coupling”), (b) Zr-catalyzed alkyne carboalumination*1, and (c) the ZACA reaction*2.

In this lecture, attention primarily was focused on recent advances in the Pd-catalyzed synthesis of alkenes, dienes, enynes, diynes, and their oligomers. Also discussed in some detail were the Zr-catalyzed alkyne carboalumination and the ZACA reaction. Their basic methodological developments and applications to complex natural products were also discussed.

Carboalumination: A reaction that Carbon-Carbon bond formation and Carbon-Aluminium bond formation generates to both ends of an unsaturated bond.
ZACA reaction: Zr-catalyzed Asymmetric Carboalumination of alkenes.

Chairperson; Prof. Ei-ichi Nakamura
(The University of Tokyo, Japan)

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