Report on the Fourth Mitsui Chemicals International Symposium on Catalysis Science (MICS2009)

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Invited Lecture

Prof. Masakatsu Shibasaki (The University of Tokyo, Japan)

Recent Progress in Asymmetric Two-Center Catalysis
Prof. Masakatsu Shibasaki

Prof. Shibasaki is one of the world leaders in the field of asymmetric catalysis. He developed the concept of two-center asymmetric catalysis consisting of a strictly designed chiral ligand and two or more metal centers that play different roles in the catalytic mechanism, such as the activation of a substrate or the control of its conformation. This concept differs from the conventional mono-metal-center catalyst concept and has led to new asymmetric reactions that have never been achieved with conventional catalysts leading to the asymmetric synthesis of pharmaceutical products.

In this lecture, he introduced new catalytic asymmetric reactions using bimetallic Schiff base complexes, the multimetallic BINOL complexes and amino acid derivatives, and catalytic asymmetric synthesis of Ranirestat and Tamiflu.

Chairperson; Prof. Kyoko Nozaki
(The University of Tokyo, Japan)

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